Acyl-CoA : cholesterol acyltransferase inhibitors from Magnolia obovata

Planta Med. 1997 Dec;63(6):550-1. doi: 10.1055/s-2006-957762.

Abstract

In the course of a search for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Liver / drug effects*
  • Liver / enzymology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Plant Leaves / chemistry*
  • Rats
  • Sterol O-Acyltransferase / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • Sterol O-Acyltransferase