The biochemical effect of auromomycin on bacterial cells

J Antibiot (Tokyo). 1979 Jul;32(7):706-10. doi: 10.7164/antibiotics.32.706.

Abstract

The mechanism of action of auromomycin was studied with intact cells of Bacillus subtilis. The antibiotic exhibited a preferential inhibition of DNA synthesis over RNA and protein syntheses. The strand scission of cellular DNA was induced by the drug, and DNA was degraded into acid-soluble fragments. The results suggested that DNA is the chemoreceptor of auromomycin.

MeSH terms

  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / pharmacology*
  • Bacillus subtilis / drug effects*
  • Bacillus subtilis / growth & development
  • Bacillus subtilis / metabolism
  • Bacterial Proteins / biosynthesis
  • DNA, Bacterial / metabolism
  • DNA, Single-Stranded / metabolism
  • Peptides / pharmacology
  • RNA, Bacterial / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Bacterial Proteins
  • DNA, Bacterial
  • DNA, Single-Stranded
  • Peptides
  • RNA, Bacterial
  • auromomycin