Leukocyte infiltration and collagenolysis in cervical tissue from intrapartum sheep

Zentralbl Veterinarmed A. 1997 Oct;44(8):501-10. doi: 10.1111/j.1439-0442.1997.tb01136.x.

Abstract

Sheep uterine cervices and cervical mucus were heavily infiltrated by neutrophils during labour, whereas samples of cervices obtained from non-pregnant controls had no infiltrate. The neutrophilic infiltrate of the sheep uterine cervix at term was not homogeneously distributed throughout the organ: luminal mucus contained more neutrophils than tissues which, in turn, displayed a differential distribution, the superficial subepithelial layer being more heavily infiltrated than the deeper submucous layers. A widespread collagenolysis was observed in the sheep uterine cervix at term. The homogeneous morphological aspect of degradation of collagen fibres throughout the whole cervical stroma contrasted with the above-mentioned differential distribution of neutrophils. On the basis of previous reports showing that collagenolysis follows the leukocytic invasion of human and rat cervices at term, a possible role for the neutrophilic infiltrate of the sheep uterine cervix is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Cervix Uteri / cytology*
  • Cervix Uteri / metabolism*
  • Cervix Uteri / ultrastructure
  • Collagen / metabolism*
  • Collagen / ultrastructure
  • Female
  • Labor, Obstetric / metabolism*
  • Labor, Obstetric / physiology
  • Microscopy, Electron / methods
  • Microscopy, Electron / veterinary
  • Microscopy, Polarization
  • Neutrophils / cytology*
  • Neutrophils / physiology
  • Neutrophils / ultrastructure
  • Pregnancy
  • Sheep / metabolism*
  • Sheep / physiology

Substances

  • Collagen