Susceptibility of 100 strains of Stenotrophomonas maltophilia to three beta-lactams and five beta-lactam-beta-lactamase inhibitor combinations

J Antimicrob Chemother. 1997 Nov;40(5):717-20. doi: 10.1093/jac/40.5.717.

Abstract

One hundred clinical strains of Stenotrophomonas maltophilia were investigated for their susceptibility to ticarcillin, piperacillin, ceftazidime and five combinations with beta-lactamase inhibitors (clavulanic acid, tazocillin or sulbactam) at three concentrations; 26% of the strains were susceptible to ticarcillin, 23% to ceftazidime and 12% to piperacillin. Eighty-two percent of the strains were susceptible to ticarcillin/clavulanic acid. In most cases, no synergy was observed with tazobactam or sulbactam. For eight ticarcillin-susceptible strains, antagonism was observed between ticarcillin and clavulanic acid.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Combinations
  • Drug Synergism
  • Enzyme Inhibitors / pharmacology*
  • Microbial Sensitivity Tests
  • Xanthomonas / drug effects*
  • beta-Lactamase Inhibitors*
  • beta-Lactams

Substances

  • Anti-Bacterial Agents
  • Drug Combinations
  • Enzyme Inhibitors
  • beta-Lactamase Inhibitors
  • beta-Lactams