Abstract
The paper deals with the formulation of a potential local anaesthetic--pentacaine into appropriate drug forms. To be more specific, the pentacaine is studies from the two aspects. First, the influence of auxiliary substances and their respective concentrations on the both onset and duration of local anaesthetic effects of pentacaine solutions. Second, the liberation of pentacaine from hydrogels and suppositories. Based on the obtained results, optimal auxiliary substances together with their optimal concentration are recommended.
MeSH terms
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Anesthesia*
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Anesthetics, Local / administration & dosage
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Anesthetics, Local / chemistry
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Anesthetics, Local / metabolism*
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Animals
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Cacao / chemistry
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Carbamates / administration & dosage
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Carbamates / chemistry
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Carbamates / metabolism*
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Carboxymethylcellulose Sodium / chemistry
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Cellulose / analogs & derivatives
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Cellulose / chemistry
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Chemistry, Pharmaceutical
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Cricetinae
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Excipients / chemistry*
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Gels
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Glycerol / chemistry
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Lactose / analogs & derivatives
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Lactose / chemistry
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Methylcellulose / analogs & derivatives
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Methylcellulose / chemistry
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Ophthalmic Solutions
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Oxazines
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Peanut Oil
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Plant Oils / chemistry
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Polymers / chemistry
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Propylene Glycols / chemistry
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Rabbits
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Sorbitol / chemistry
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Suppositories
Substances
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Anesthetics, Local
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Carbamates
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Excipients
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Gels
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Ophthalmic Solutions
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Oxazines
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Peanut Oil
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Plant Oils
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Polymers
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Propylene Glycols
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Suppositories
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polypropylene glycol
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Sorbitol
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pentacaine
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Cellulose
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hydroxyethylcellulose
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Methylcellulose
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MK 458
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Lactose
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Carboxymethylcellulose Sodium
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Glycerol