Mitotane (o,p'-DDD) treatment in a cat with hyperadrenocorticism

J Small Anim Pract. 1997 Nov;38(11):520-4. doi: 10.1111/j.1748-5827.1997.tb03310.x.

Abstract

An 11-year-old male castrated Persian cat with spontaneous hyperadrenocorticism was presented. Both adrenals were grossly enlarged and calcified. A diagnosis of pituitary-dependent hyperadrenocorticism was made. Signs of hyperadrenocorticism resolved with long-term mitotane treatment. Concurrent diabetes mellitus resolved after 220 days of therapy. No severe adverse drug reactions were noted.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex / diagnostic imaging
  • Adrenal Cortex / pathology
  • Adrenocortical Hyperfunction / drug therapy
  • Adrenocortical Hyperfunction / pathology
  • Adrenocortical Hyperfunction / veterinary*
  • Animals
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Blood Glucose / analysis
  • Cat Diseases / blood
  • Cat Diseases / drug therapy*
  • Cat Diseases / pathology
  • Cats
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / veterinary
  • Dose-Response Relationship, Drug
  • Hydrocortisone / blood
  • Insulin / therapeutic use
  • Male
  • Mitotane / therapeutic use*
  • Radiography
  • Time Factors
  • Ultrasonography

Substances

  • Antineoplastic Agents, Hormonal
  • Blood Glucose
  • Insulin
  • Mitotane
  • Hydrocortisone