Abstract
The synthesis of 2-halo-1-adamantanemethanamines, 4-protoadamantanemethanamines, and 4-protoadamantaneamines is described. The anti-Parkinson activity of these amines in terms of reversal of reserpine-induced catalepsy in rats has been evaluated and compared with amantadine. 2-Bromo- and 2-chloro-1-adamantanemethanamines are shown to be twice as active as amantadine.
MeSH terms
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Adamantane / analogs & derivatives
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Adamantane / chemical synthesis*
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Adamantane / pharmacology
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Adamantane / toxicity
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Amines / chemical synthesis
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Amines / pharmacology
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Amines / toxicity
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Animals
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Antiparkinson Agents / chemical synthesis*
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Antiparkinson Agents / toxicity
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Body Temperature / drug effects
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Bridged-Ring Compounds / chemical synthesis*
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Lethal Dose 50
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Mice
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Motor Activity / drug effects
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Rats
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Reserpine / antagonists & inhibitors
Substances
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Amines
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Antiparkinson Agents
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Bridged-Ring Compounds
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Reserpine
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Adamantane