Abstract
Plant disease resistance (R) genes confer an ability to resist infection by pathogens expressing specific corresponding avirulence genes. In Arabidopsis thaliana, resistance to both bacterial and fungal pathogens, mediated by several R gene products, requires the NDR1 gene. Positional cloning was used to isolate NDR1, which encodes a 660-base pair open reading frame. The predicted 219-amino acid sequence suggests that NDR1 may be associated with a membrane. NDR1 expression is induced in response to pathogen challenge and may function to integrate various pathogen recognition signals.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Arabidopsis / genetics*
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Arabidopsis / microbiology*
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Arabidopsis Proteins*
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Chromosome Mapping
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Chromosomes, Artificial, Yeast
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Cloning, Molecular
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Cosmids
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Gene Expression Regulation, Plant
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Genes, Plant
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Immunity, Innate / genetics
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Membrane Proteins / chemistry
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Molecular Sequence Data
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Oomycetes / pathogenicity
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Open Reading Frames
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Plant Diseases / genetics*
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Plant Proteins / chemistry
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Plant Proteins / genetics*
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Plant Proteins / physiology
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Pseudomonas / pathogenicity
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Signal Transduction
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Transcription Factors*
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Transformation, Genetic
Substances
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Arabidopsis Proteins
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Membrane Proteins
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NDR1 protein, Arabidopsis
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Plant Proteins
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Transcription Factors