Inhibition of bacterial growth by synthetic SP-B1-78 peptides

Peptides. 1997;18(9):1441-4. doi: 10.1016/s0196-9781(97)00211-8.

Abstract

Residues 12-34 of mature human pulmonary surfactant protein B (SP-B1-78) are 68% homologous to residues 48-72 of the frog peptide antibiotic dermaseptin b I. We examined the effects of SP-B1-78 on the growth of Escherichia coli in order to find whether full length SP-B1-78 might act as a peptide antibiotic. We found that SP-B1-78 peptide inhibited growth of E. coli (MIC = 210 micrograms.ml-1), but that the SP-B variant [R/K-->S]SP-B1-78 was less potent (MIC = 500 micrograms.ml-1).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Analysis of Variance
  • Escherichia coli / drug effects*
  • Escherichia coli / growth & development
  • Growth Inhibitors / pharmacology*
  • Molecular Sequence Data
  • Peptide Fragments / pharmacology*
  • Proteolipids / chemistry
  • Proteolipids / pharmacology*
  • Pulmonary Surfactants / chemistry
  • Pulmonary Surfactants / pharmacology*

Substances

  • Growth Inhibitors
  • Peptide Fragments
  • Proteolipids
  • Pulmonary Surfactants