[Changes of superoxide dismutase and lipid peroxide in lung tissue of rats after intratracheal injection of crocidolite and benzo(a) pyrene]

Hua Xi Yi Ke Da Xue Xue Bao. 1996 Sep;27(3):266-9.
[Article in Chinese]

Abstract

Wistar rats were divided into 4 groups: control group, Cro group, B(a) p group and Cro plus B(a) p group. Samples of lung tissue were collected 90, 180, 270, 360 and 540 days after the third time of intratracheal. The superoxide dismutase (SOD) activity, the level of lipid peroxide (LPO) and the ratio of SOD/LPO were observed. The results indicated that there was a synergistic action of Cro. and B(a) p.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asbestos, Crocidolite
  • Benzo(a)pyrene
  • Carcinoma, Squamous Cell / chemically induced
  • Carcinoma, Squamous Cell / metabolism*
  • Female
  • Injections
  • Lipid Peroxides / metabolism*
  • Lung / metabolism*
  • Lung / pathology
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / metabolism*
  • Male
  • Rats
  • Superoxide Dismutase / metabolism*

Substances

  • Lipid Peroxides
  • Asbestos, Crocidolite
  • Benzo(a)pyrene
  • Superoxide Dismutase