New insights from spectroscopy into the structure/function relationships of lipoxygenases

Chem Biol. 1997 Nov;4(11):795-808. doi: 10.1016/s1074-5521(97)90113-7.

Abstract

Spectroscopic properties of the redox-active iron in the active site of plant and mammalian lipoxygenases can now be combined with recent crystal structure determinations to obtain new insights into lipoxygenase reaction mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Crystallography, X-Ray
  • Glycine max / enzymology
  • Iron / metabolism
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism*
  • Lipoxygenase / chemistry
  • Lipoxygenase / metabolism*
  • Models, Molecular
  • Oxidation-Reduction
  • Protein Conformation
  • Spectrophotometry
  • Structure-Activity Relationship

Substances

  • Isoenzymes
  • Iron
  • Lipoxygenase