Synthesis and antibacterial evaluation of [1,3]benzothiazino[3,2-a]quinoline- and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acid derivatives

V Cecchetti; G Cruciani; E Filipponi; A Fravolini; O Tabarrini; T Xin

doi:10.1016/s0968-0896(97)00084-9

Synthesis and antibacterial evaluation of [1,3]benzothiazino[3,2-a]quinoline- and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acid derivatives

Bioorg Med Chem. 1997 Jul;5(7):1339-44. doi: 10.1016/s0968-0896(97)00084-9.

Authors

V Cecchetti¹, G Cruciani, E Filipponi, A Fravolini, O Tabarrini, T Xin

Affiliation

¹ Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.

PMID: 9377094
DOI: 10.1016/s0968-0896(97)00084-9

Abstract

A series of [1,3]benzothiazino[3,2-a]quinoline- (5) and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acids (10) were synthesized and evaluated for their in vitro antibacterial activity. The activity is discussed in terms of their structural features revealed by molecular orbital correlation.

MeSH terms

4-Quinolones
Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Chemical Phenomena
Chemistry, Physical
Microbial Sensitivity Tests
Models, Molecular
Structure-Activity Relationship
Thermodynamics
Thiazines / chemical synthesis*
Thiazines / chemistry
Thiazines / pharmacology*

Substances

4-Quinolones
Anti-Infective Agents
Thiazines