Abstract
A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Dimerization
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology*
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Humans
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Tumor Cells, Cultured
Substances
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Antimalarials
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Antineoplastic Agents
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Heterocyclic Compounds