Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males

Int J Obes Relat Metab Disord. 1997 Sep;21(9):822-5. doi: 10.1038/sj.ijo.0800483.

Abstract

In 1474 healthy Caucasoid men aged 45-65 y, insulin-like growth factor II (IGF2) Apal AA homozygotes showed a mean body weight 4 kg lower than Apal GG homozygotes (77.6 +/- 10.9 kg vs 81.6 +/- 11.5 kg, P = 0.003) with heterozygotes (GA) intermediate (80.1 +/- 11.9 kg). The mean serum IGF-II concentration in 44 Apal AA individuals was significantly higher than in 48 Apal GG individuals (683.3 +/- 146.9 ng/ml vs 614.0 +/- 124.0 ng/ml, P = 0.01). An INS Pstl polymorphism showed no association with weight and it was also found to be in minimal linkage disequilibrium with the IGF2 Apal site (coefficient 0.016). The IGF2 Apal AA genotype is therefore associated with lower mean body weight but higher serum IGF-II concentrations than the GG genotype. Apal GG homozygotes incur a 1.67-fold risk of pathological Body Mass index (BMI) (> 30 kg/m2) compared with AA homozygotes.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Body Mass Index
  • Body Weight / genetics*
  • Cholesterol / blood
  • DNA Primers / chemistry
  • Genotype
  • Homozygote
  • Humans
  • Insulin-Like Growth Factor II / analysis
  • Insulin-Like Growth Factor II / chemistry
  • Insulin-Like Growth Factor II / genetics*
  • Leucine / analogs & derivatives*
  • Leucine / genetics
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Triglycerides / blood
  • White People / genetics

Substances

  • DNA Primers
  • Triglycerides
  • aminophenylacetylleucine
  • Insulin-Like Growth Factor II
  • Cholesterol
  • Leucine