[The embryotoxic action of fragment C-I-6 of human interleukin-2]

Eksp Klin Farmakol. 1997 Jul-Aug;60(4):74-5.
[Article in Russian]

Abstract

The peptide C-I-6 is a modified fragment (sequence 59-72) of human interleukin-2 and stimulates regeneration of hepatic cells and tissues. Study of the possible embryotoxic and teratogenic properties of C-I-6 showed that in some cases it induces the following statistically significant changes: reduces the number of viable fetus, increases the occurrence of hydronephrosis and the number of external and internal hematomas, increases the weight and size of the embryo. It is concluded that intraperitoneal administration of C-I-6 causes a mild embryotoxic and teratogenic effect in rats.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Embryo, Mammalian / drug effects*
  • Female
  • Humans
  • Interleukin-2 / toxicity*
  • Male
  • Peptide Fragments / toxicity*
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rats
  • Rats, Wistar
  • Specific Pathogen-Free Organisms
  • Teratogens / toxicity*
  • Time Factors

Substances

  • Interleukin-2
  • Peptide Fragments
  • Teratogens
  • peptide C-I-6