Abstract
The formyl tripeptides containing 2-azetidinecarboxylic acid 2, 2-piperidinecarboxylic acid 3 and norvaline 4 in position 2 were synthesized and their biological activity was evaluated. The conformation of peptides was studied by CD and FT-IR techniques. While 2 and 3 do not show either chemotactic activity or superoxide production, 4 retains both activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Movement
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Chemotactic Factors / chemistry*
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Chemotactic Factors / pharmacology
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Humans
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N-Formylmethionine Leucyl-Phenylalanine / analogs & derivatives*
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N-Formylmethionine Leucyl-Phenylalanine / chemistry
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Neutrophils / physiology
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Oligopeptides / chemistry*
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Oligopeptides / pharmacology
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Protein Conformation
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Solutions
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Superoxides / metabolism
Substances
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Chemotactic Factors
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Oligopeptides
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Solutions
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Superoxides
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N-Formylmethionine Leucyl-Phenylalanine
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formylmethionyl-leucyl-phenylalanine methyl ester