Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation

J Med Chem. 1997 Oct 24;40(22):3489-93. doi: 10.1021/jm9704107.
No abstract available

MeSH terms

  • Animals
  • Binding Sites
  • Crystallography, X-Ray
  • Humans
  • Serine Proteinase Inhibitors / chemistry
  • Serine Proteinase Inhibitors / pharmacology*
  • Structure-Activity Relationship
  • Thiophenes / chemistry
  • Thiophenes / pharmacology*
  • Thrombin / antagonists & inhibitors*

Substances

  • Serine Proteinase Inhibitors
  • Thiophenes
  • benzothiophene
  • Thrombin