The need for sedative therapy in the critical care setting is well established. It is an absolute therapeutic adjunct useful in decreasing both patient morbidity and mortality. Sedative endpoints, monitoring requirements, and recommended agents and dosages associated with sedation, however, remain poorly defined. Standardization is the key to optimal patient outcome at minimal cost. This article presents an overview of current trends and recommendations. Continuing research into these areas is strongly recommended to ensure consistent and safe practice.