Vibrio vulnificus, a virulent gram-negative organism, is a normal inhabitant of coastal waters, including the Gulf of Mexico. Vibrio vulnificus infection has been recognized as a cause of fatal septicemia in chronically ill patients, particularly those with chronic liver disease. We report the case of a patient with chronic liver disease who had V vulnificus septicemia 2 days after eating raw oysters harvested in the Gulf Coast. Vibrio vulnificus septicemia should be suspected in all patients with underlying medical illnesses, particularly cirrhosis, who present with a febrile illness days after eating seafood or being exposed to saltwater. Physicians should advise their patients with cirrhosis and other chronic debilitating illnesses not to eat raw or undercooked seafood.