Phytochemical analysis of Geigeria alata and Francoeuria crispa essential oils

Planta Med. 1997 Oct;63(5):479-82. doi: 10.1055/s-2006-957743.

Abstract

Phytochemical analyses of Geigeria alata (Benth. & Hook.) and Francoeuria crispa (Forssk., Cas.) (Asteraceae) essential oils were performed. G. alata oil showed moderate in vitro cytotoxicity (IC50, micrograms/ml against tumor cells; P388: 2.0, A-549: 2.5 and HT-29: 5.0), and also showed weak anti-HIV activity. S-Carvotanacetone, the major component of F. crispa oil (93.0%), was isolated and its structure was elucidated by 2D-NMR analysis.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / toxicity
  • Cell Survival / drug effects
  • Gas Chromatography-Mass Spectrometry
  • HIV / drug effects
  • HIV / physiology*
  • Humans
  • Leukemia P388
  • Mice
  • Oils, Volatile / analysis*
  • Plants, Medicinal*
  • Plants, Toxic*
  • Tumor Cells, Cultured
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Antineoplastic Agents, Phytogenic
  • Oils, Volatile