Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma

Acta Neurochir (Wien). 1997;139(8):749-55. doi: 10.1007/BF01420048.

Abstract

Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. The association with this malignant eye disease as well as the effect of irradiation and multi-agent chemotherapy on second tumour induction are evaluated.

Publication types

  • Case Reports

MeSH terms

  • Chemotherapy, Adjuvant
  • Child
  • Combined Modality Therapy
  • Eye Enucleation
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Invasiveness
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / genetics
  • Neuroectodermal Tumors, Primitive / diagnosis*
  • Neuroectodermal Tumors, Primitive / genetics
  • Optic Nerve / pathology
  • Postoperative Complications / diagnosis*
  • Radiotherapy, Adjuvant
  • Retinal Neoplasms / genetics
  • Retinal Neoplasms / therapy*
  • Retinoblastoma / genetics
  • Retinoblastoma / therapy*
  • Risk Factors
  • Supratentorial Neoplasms / diagnosis*
  • Supratentorial Neoplasms / genetics