Detection of a dup(17q) and inv(16) by fluorescence in situ hybridization in acute myelomonocytic leukemia

Cancer Genet Cytogenet. 1997 Oct 1;98(1):87-9. doi: 10.1016/s0165-4608(96)00394-9.

Abstract

Two cases of acute myelomonocytic leukemia (AMMoL) of FAB type M4Eo are described in which a primary subclone containing a dup(17)(q21q25) and a subclone containing dup(17)(q21q25), inv(16)(p13q22) were seen in one patient, and -7, dup(17)(q21q25) in another. Fluorescence in situ hybridization (FISH) was carried out for the confirmation of the duplicated segment and breakpoint of inv(16). Inv(16) is a well known anomaly in AMMoL, whereas dup(17q) is rare though as not yet confirmed, this anomaly could be a nonrandom or novel change in AMMoL.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Chromosome Aberrations*
  • Female
  • Humans
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myelomonocytic, Acute / drug therapy
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Leukemia, Myelomonocytic, Acute / immunology
  • Male
  • Middle Aged