Abstract
Amiodarone is a drug broadly used on cardiac arrhythmias despite its multiple side-effects. We present the case of an adult male with symptomatic ventricular tachycardia, receiving longterm amiodarone, who showed increased CK serum levels, sensorimotor neuropathy and secondary myopathy. Quadriceps biopsy showed atrophic changes and sural nerve intralysosomal deposits with intense axonal degeneration. The case illustrates the need to investigate and monitor peripheral neuropathy and muscular atrophy in chronic amiodarone use.
MeSH terms
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Adult
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Amiodarone / adverse effects*
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Amiodarone / pharmacology
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Anti-Arrhythmia Agents / adverse effects*
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Atrophy
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Creatine Kinase / blood
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Enzyme Inhibitors / adverse effects
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Enzyme Inhibitors / pharmacology
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Humans
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Inclusion Bodies / ultrastructure
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Isoenzymes
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Lysosomes / enzymology
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Lysosomes / ultrastructure
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Male
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Muscle, Skeletal / pathology
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Nerve Degeneration
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Neural Conduction
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Neuromuscular Diseases / blood
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Neuromuscular Diseases / chemically induced*
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Neuromuscular Diseases / pathology
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Paresthesia / chemically induced
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Phospholipases / antagonists & inhibitors
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Sural Nerve / pathology
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Tachycardia, Ventricular / drug therapy
Substances
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Anti-Arrhythmia Agents
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Enzyme Inhibitors
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Isoenzymes
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Creatine Kinase
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Phospholipases
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Amiodarone