Acyclic glycosidopyrroles analogues of ganciclovir: synthesis and biological activity

Farmaco. 1997 May;52(5):281-2.

Abstract

Acyclic glycosidopyrroles of type 3 were synthetized in good overall yields, according to the Scheme. When evaluated for antiviral activity against DNA and RNA viruses, only compound in which R1 = R2 = Ph, R3 = NH2 was found to inhibit the HIV-1 replication at concentrations that were not cytotoxic for MT-4 cells.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Ganciclovir / analogs & derivatives*

Substances

  • Antiviral Agents
  • Ganciclovir