Physico-chemical properties and stability of the new hypoxia-selective agent 7-chloro-3-[[N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride

Arzneimittelforschung. 1997 Jul;47(7):873-8.

Abstract

7-Chloro-3-[[N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitril e 1,4-di-N-oxide hydrochloride (Q-85 HCl), a new hypoxia-selective agent, was studied to clarify its physico-chemical properties. Melting point, spectra (UV, IR, NMR, MS), thermal behaviour, solubility, pKa, partition coefficient and chromatographic characteristics (TLC, HPLC) have been determined. The stability of Q-85 HCl was studied under various conditions by HPLC. Q-85 HCl in solid state was very stable to heat and fairly stable to light. Some degradation products of Q-85 HCl were identified in basic solution.

MeSH terms

  • Calorimetry, Differential Scanning
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Drug Stability
  • Magnetic Resonance Spectroscopy
  • Quinoxalines / chemistry*
  • Solubility
  • Solutions
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Thermogravimetry

Substances

  • 7-chloro-3-(((N,N-dimethylamino)propyl)amino)-2-quinoxalinecarbonitrile-1,4-di-N-oxide
  • Quinoxalines
  • Solutions