Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides

K Cimanga; T de Bruyne; B Van Poel; Y Ma; M Claeys; L Pieters; K Kambu; L Tona; P Bakana; D Vanden Berghe; A J Vlietinck

doi:10.1055/s-2006-957657

Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides

Planta Med. 1997 Jun;63(3):220-3. doi: 10.1055/s-2006-957657.

Authors

K Cimanga¹, T de Bruyne, B Van Poel, Y Ma, M Claeys, L Pieters, K Kambu, L Tona, P Bakana, D Vanden Berghe, A J Vlietinck

Affiliation

¹ Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Belgium.

PMID: 9265193
DOI: 10.1055/s-2006-957657

Abstract

A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1-->6)]-[beta-D-glucopyranosyl-(1-->2)]-be ta-D-glucopyranoside, a new natural product which was named morindaoside.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Complement Activation / drug effects*
Flavonoids*
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology
Kaempferols*
Medicine, Traditional
Molecular Sequence Data
Molecular Structure
Plant Leaves
Plants, Medicinal*
Quercetin / analogs & derivatives*
Quercetin / chemistry
Quercetin / isolation & purification
Quercetin / pharmacology

Substances

Flavonoids
Glycosides
Kaempferols
morindaoside
kaempferol
Quercetin