Galantide improves social memory in rats

Pharmacol Res. 1997 Apr;35(4):317-9. doi: 10.1006/phrs.1997.0150.

Abstract

The role of galanin in memory paradigms has been largely evaluated. The galanin-antagonist galantide, a chimeric peptide obtained from amino acids 1-13 of galanin attached to the C-terminal fragment of bradykinin, has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000 nmoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cognition / drug effects
  • Cues
  • Galanin / analogs & derivatives*
  • Galanin / pharmacology
  • Injections, Intraventricular
  • Male
  • Memory / drug effects*
  • Rats
  • Rats, Wistar
  • Social Behavior*
  • Substance P / analogs & derivatives*
  • Substance P / pharmacology

Substances

  • galantide
  • Substance P
  • Galanin