Abstract
This study investigated how chronic perinatal reduction of nerve growth factor (NGF) affected brain cholinergic markers in the two sexes. Rats received anti-NGF on postnatal days (PNDs) 2-12, and choline acetyltransferase (ChAT) activity was measured on PND 16. Anti-NGF significantly reduced cortical ChAT activity in males, but not in females; no sex-dependent effects were found in hippocampus or striatum. These data suggest sexual dimorphism in cholinergic responsiveness to NGF.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn / physiology*
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Brain / enzymology
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Brain / growth & development*
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Brain Chemistry / physiology
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Cerebral Cortex / enzymology
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Cerebral Cortex / growth & development
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Cerebral Cortex / metabolism
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Choline O-Acetyltransferase / metabolism
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Female
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Hippocampus / enzymology
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Hippocampus / growth & development
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Hippocampus / metabolism
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Male
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Neostriatum / enzymology
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Neostriatum / growth & development
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Neostriatum / metabolism
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Nerve Growth Factors / physiology*
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Parasympathetic Nervous System / drug effects
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Parasympathetic Nervous System / growth & development
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Rats
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Rats, Wistar
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Sex Characteristics
Substances
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Nerve Growth Factors
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Choline O-Acetyltransferase