Expression of cyclooxygenase-2 mRNA in rat retrosplenial cortex following administration of phencyclidine

Brain Res. 1997 Jul 11;762(1-2):259-63. doi: 10.1016/s0006-8993(97)00505-2.

Abstract

The effect of NMDA receptor antagonist phencyclidine (PCP) on expression of cyclooxygenase (COX)-2 mRNA in the rat brain was studied. Administration of PCP (12.5, 25 or 50 mg/kg, i.p., 6 h) caused marked induction of COX-2 mRNA and heat shock gene hsp-70 mRNA, a marker of neuronal injury, in the retrosplenial cortex, in a dose-dependent manner. These results suggest that COX-2 may play a role in the neurotoxicity of NMDA receptor antagonists.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Cerebral Cortex / chemistry
  • Cerebral Cortex / enzymology*
  • Cyclooxygenase 2
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects
  • HSP70 Heat-Shock Proteins / genetics
  • In Situ Hybridization
  • Isoenzymes / genetics*
  • Peroxidases / genetics
  • Phencyclidine / pharmacology*
  • Prostaglandin-Endoperoxide Synthases / genetics*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors

Substances

  • Excitatory Amino Acid Antagonists
  • HSP70 Heat-Shock Proteins
  • Isoenzymes
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate
  • Peroxidases
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Phencyclidine