New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica

J Nat Prod. 1997 Jul;60(7):739-42. doi: 10.1021/np970010m.

Abstract

A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Lignans / chemistry
  • Lignans / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Plants, Medicinal / chemistry*

Substances

  • 7-hydroxy-3',4'-(methylenedioxy)flavan
  • Anti-HIV Agents
  • Antifungal Agents
  • Antimalarials
  • Flavonoids
  • Lignans