Abstract
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults. Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions. We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy. The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.
MeSH terms
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Adult
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Antithyroid Agents / adverse effects*
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Antithyroid Agents / therapeutic use
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Female
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Graves Disease / drug therapy
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Humans
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Male
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Middle Aged
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Propylthiouracil / adverse effects*
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Propylthiouracil / therapeutic use
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Skin Diseases / chemically induced*
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Skin Diseases / diagnosis
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Skin Diseases / pathology
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Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*
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Vasculitis, Leukocytoclastic, Cutaneous / diagnosis
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Vasculitis, Leukocytoclastic, Cutaneous / pathology
Substances
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Antithyroid Agents
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Propylthiouracil