In a series of patients with neuroinfection, Lyme disease, Guillain Barré syndrome, demyelinization, partial or generalized, epilepsy, we have investigated antiphospholipid antibodies of IgG and IgM subtypes, together with anticoagulant factors, member of thrombocytes, sedimentation rate of erythrocytes. Coagulant factor disorder in primary acute inflammatory processes (attack of demyelinization, neuroinfection, acute viral respiratory infection) and primary thrombocyte disorder (focal epilepsies) may be a result of cross reaction of antiphospholipid antibodies with negative polarized phospholipids in membranes of central nervous system, endothelium of cerebral and extracranial vessels and in the inner thrombocyte membranes connected with prostaglandin production disorder.