Structure-activity relationships of sandalwood odorants: synthesis and odour of methyl-beta-santalol

Arch Pharm (Weinheim). 1997 Apr;330(4):112-4. doi: 10.1002/ardp.19973300407.

Abstract

The synthesis and odour properties of the new santalol analogue, methyl-beta-santalol, are described. The additional methyl group adjacent to the hydroxyl function of the standard molecule, beta-santalol, deprives the new compound of the sandalwood note. The synthesis and the odour evaluation of this compound supports the proposed model for sandalwood fragrance as it shows that the methyl group located at the osmophoric center prevents association of the molecule with the hypothetical receptor.

MeSH terms

  • Coumarins / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Structure
  • Odorants
  • Plant Oils*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology
  • Structure-Activity Relationship

Substances

  • Coumarins
  • Plant Oils
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • santalol
  • sandalwood oil