Abstract
Hypothalamic-pituitary-adrenal (HPA) axis activity and platelet 5-HT concentrations were determined before dexamethasone suppression test (DST) in 80 male schizophrenic patients with predominantly positive or negative symptoms. Significant differences in platelet 5-HT and no differences in baseline plasma cortisol concentrations among schizophrenic suppressors and nonsuppressors were found. A similar rate of nonsuppression (56% positive and 53% negative schizophrenic patients) was detected. Platelet 5-HT, but not plasma cortisol concentrations, could be used to differentiate positive and negative symptoms of schizophrenia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Arousal / physiology
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Blood Platelets / metabolism*
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Delusions / diagnosis
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Delusions / physiopathology
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Delusions / psychology
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Depression / diagnosis
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Depression / physiopathology
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Depression / psychology
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Dexamethasone
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Diagnosis, Differential
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Hallucinations / diagnosis
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Hallucinations / physiopathology
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Hallucinations / psychology
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Humans
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Hydrocortisone / blood
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Hypothalamo-Hypophyseal System / physiopathology*
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Male
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Pituitary-Adrenal System / physiopathology*
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Psychiatric Status Rating Scales*
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Schizophrenia / diagnosis
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Schizophrenia / physiopathology*
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Schizophrenic Psychology*
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Serotonin / blood*
Substances
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Serotonin
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Dexamethasone
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Hydrocortisone