Abstract
We have conducted a trial according to double-blind, double-dummy conditions, comparing flurythromycin ethylsuccinate with clarithromycin treatments. Sensitive pathogenic bacteria were isolated according to the Kirby Bauer method from sputum cultures of 152 patients affected by acute infections of lower airways (bronchitis, bronchopneumonia, etc.). The activities of the 2 drugs were investigated on the basis of a main bacteriological evaluation and of several secondary criteria; the 2 treatments were effective and tolerated to the same extent. It can be concluded that in the treatment of infections of lower respiratory airways the use of flurythromycin offers some advantages.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Analysis of Variance
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Bacteria / drug effects
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Bacterial Infections / drug therapy*
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Bacterial Infections / microbiology
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Clarithromycin / administration & dosage
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Clarithromycin / pharmacology
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Clarithromycin / therapeutic use*
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Culture Media
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Double-Blind Method
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Erythromycin / administration & dosage
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Erythromycin / analogs & derivatives
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Erythromycin / pharmacology
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Erythromycin / therapeutic use
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Female
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Reference Standards
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Respiratory Tract Infections / drug therapy*
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Respiratory Tract Infections / microbiology
Substances
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Anti-Bacterial Agents
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Culture Media
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flurithromycin
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Erythromycin
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Clarithromycin