Abstract
Sixty-five patients with uterine myomas were studied after surgery to investigate the effect of periodic GnRH analog treatment on the prevention of recurrences. A group of patients was treated by leuprolide acetate depot 3 months a year for 3 years. At the end of treatment, these patients showed a significantly reduced uterine volume and myoma recurrence rate as compared to untreated patients. A role of GnRH analogs in the clinical prevention of myoma recurrence could be suggested.
MeSH terms
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Adult
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Delayed-Action Preparations
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Female
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Gonadotropin-Releasing Hormone / analogs & derivatives*
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Humans
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Incidence
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Leiomyoma / epidemiology
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Leiomyoma / prevention & control*
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Leiomyoma / surgery*
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Leuprolide / administration & dosage
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Leuprolide / pharmacology*
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Neoplasm Recurrence, Local / diagnostic imaging
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Neoplasm Recurrence, Local / epidemiology
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Neoplasm Recurrence, Local / prevention & control*
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Pilot Projects
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Postoperative Care*
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Ultrasonography
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Uterine Neoplasms / epidemiology
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Uterine Neoplasms / prevention & control*
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Uterine Neoplasms / surgery*
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Uterus / diagnostic imaging
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Uterus / pathology
Substances
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Delayed-Action Preparations
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Gonadotropin-Releasing Hormone
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Leuprolide