Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase

Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases*
  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 5
  • Cyclic AMP / metabolism
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Kinetics
  • Molecular Sequence Data
  • Multigene Family
  • Phosphodiesterase Inhibitors / pharmacology*
  • Phosphoric Diester Hydrolases / chemistry*
  • Phosphoric Diester Hydrolases / genetics*
  • Phosphoric Diester Hydrolases / metabolism
  • Protein Conformation
  • Pyrrolidinones / pharmacology*
  • Rats
  • Rolipram
  • src Homology Domains*

Substances

  • Isoenzymes
  • Phosphodiesterase Inhibitors
  • Pyrrolidinones
  • Cyclic AMP
  • Phosphoric Diester Hydrolases
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • PDE4A protein, human
  • Rolipram

Associated data

  • GENBANK/L20965
  • GENBANK/L27057
  • GENBANK/L36467
  • GENBANK/M26715
  • GENBANK/M37744
  • GENBANK/U18087
  • GENBANK/U18088