Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice

Brain Res Mol Brain Res. 1997 Jun;46(1-2):333-7. doi: 10.1016/s0169-328x(97)00081-8.

Abstract

L7/pcp-2 is expressed exclusively in cerebellar Purkinje and retinal bipolar neurons. While the function of L7/pcp-2 is unknown, its mRNA is trafficked into dendrites, suggesting a role in dendritic physiology. To elucidate its function, L7/pcp-2-null mice were generated. These mice are neurologically normal with no signs of cerebellar or retinal dysfunction. The mice are indistinguishable from wild-type littermates with regards to gross neuroanatomy and fine structure of Purkinje cell dendrites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Guanine Nucleotide Exchange Factors
  • Mice
  • Mice, Inbred C57BL
  • Neuropeptides / physiology*
  • Purkinje Cells / physiology*
  • Retina / physiology*

Substances

  • Guanine Nucleotide Exchange Factors
  • Neuropeptides
  • Pcp2 protein, mouse