Abstract
We describe a patient in whom bilateral swelling of submandibular glands was the initial manifestation of limited Wegener's disease. The diagnosis was based on positive anti-neutrophil cytoplasmic antibody [C-ANCA], dense inflammatory infiltrate predominantly of lymphocytes in submandibular glands, presence of non-caseating ill-formed granulomas in transbronchial biopsy and resolution of symptoms following immuno-suppressive treatment.
MeSH terms
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Antibodies, Antineutrophil Cytoplasmic / analysis
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Biopsy
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Bronchoscopy
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Granulomatosis with Polyangiitis / complications*
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Granulomatosis with Polyangiitis / diagnosis
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Granulomatosis with Polyangiitis / drug therapy
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Humans
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Immunosuppressive Agents / therapeutic use
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Male
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Middle Aged
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Salivary Gland Diseases / complications*
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Salivary Gland Diseases / diagnosis
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Salivary Gland Diseases / drug therapy
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Submandibular Gland / diagnostic imaging
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Submandibular Gland / pathology*
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Tomography, X-Ray Computed
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Immunosuppressive Agents