Purpose: To report acute progressive multifocal Best's disease in patients in their seventh decade.
Method: We report one such case.
Results: We examined a 61-year-old man with strikingly symmetric, 1-disk diameter serous retinal detachments involving each fovea. Fluorescein angiography was unremarkable, with no dye leakage. Electrophysiologic testing confirmed the diagnosis. Visual acuity decreased, and within 1 month, the size and number of lesions rapidly increased. Three months later, the lesions quickly evolved to the classic vitelliform stage.
Conclusion: This well-documented case expands the spectrum of findings in multifocal Best's disease.