Comparison of parametrized models for computer-based estimation of diabetic patient glucose response

Med Inform (Lond). 1997 Jan-Mar;22(1):21-34. doi: 10.3109/14639239709089832.

Abstract

Two mathematical models for the description of diabetic patient glucose behaviour are proposed. Unlike high order differential-equation based compartmental models, these models employ only the data typically available to a diabetic patient: the history of measured blood glucose concentrations and of insulin injections. The model structures are compared with a native benchmark (zero-order hold) model in a computer simulation. It is demonstrated that, given four daily blood glucose measurements and two daily insulin injections, a parametrized model of patient blood glucose response to insulin can provide relevant data in the estimation of a patient's future blood glucose response in terms of past blood glucose measurements and insulin injections. Parametrized model root means squared errors of glycaemic predictions for 18 simulated patients ranged from 7-22 mg dl-1, as compared with 19-42 mg dl-1 for the benchmark model.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Computer Simulation
  • Diabetes Mellitus / therapy*
  • Glucose / metabolism*
  • Humans
  • Insulin / administration & dosage
  • Insulin / pharmacology*
  • Least-Squares Analysis
  • Linear Models
  • Models, Biological*
  • Therapy, Computer-Assisted*

Substances

  • Insulin
  • Glucose