Synthesis of amides with anti-inflammatory and analgesic activities

Farmaco. 1997 Feb;52(2):93-8.

Abstract

A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. One compound, N-benzoyl-4-methyl-cyclohexylamide 6a, possessed an anti-inflammatory activity comparable to that of indomethacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis*
  • Amides / pharmacology
  • Amides / toxicity
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Carrageenan
  • Edema / chemically induced
  • Edema / prevention & control
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Indomethacin / pharmacology
  • Indomethacin / toxicity
  • Male
  • Mice
  • Pain Measurement / drug effects
  • Rats
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / pathology

Substances

  • Amides
  • Anti-Inflammatory Agents, Non-Steroidal
  • Carrageenan
  • Indomethacin