Abstract
A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. One compound, N-benzoyl-4-methyl-cyclohexylamide 6a, possessed an anti-inflammatory activity comparable to that of indomethacin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Amides / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Female
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Gas Chromatography-Mass Spectrometry
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Indomethacin / pharmacology
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Indomethacin / toxicity
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Male
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Mice
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Pain Measurement / drug effects
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Rats
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Stomach Ulcer / chemically induced
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Stomach Ulcer / pathology
Substances
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Amides
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Anti-Inflammatory Agents, Non-Steroidal
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Carrageenan
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Indomethacin