Chronic intrarenal infusion of low-dose angiotensin II in dogs increases arterial pressure without impairment of renal function

Clin Exp Pharmacol Physiol. 1997 Jun;24(6):439-41. doi: 10.1111/j.1440-1681.1997.tb01219.x.

Abstract

1. To determine whether chronic angiotensin II (AngII) infusion into the renal artery, at a dose which increases systemic arterial pressure, reduces glomerular filtration rate (GFR) and renal blood flow, AngII was infused at 0.5 ng/kg per min into the renal artery or intravenously in chronically instrumented dogs for 1 month. 2. Mean arterial pressure (MAP) rose significantly (P < 0.05) during the infusion of AngII into the renal artery (+7 +/- 2 mmHg on days 26-30). There were no significant changes in GFR or renal blood flow. When the same dose of AngII was infused intravenously, MAP did not change significantly (-2 +/- 2 mmHg) and there were no significant changes in GFR or in renal blood flow. 3. We conclude that AngII infused into the renal artery for 1 month, at a dose which was initially subpressor, causes a rise in arterial pressure that is not associated with impairment of renal function.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / administration & dosage*
  • Animals
  • Blood Pressure / drug effects*
  • Creatinine / blood
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Glomerular Filtration Rate / drug effects
  • Infusions, Intra-Arterial
  • Infusions, Intravenous
  • Kidney / blood supply
  • Kidney / drug effects*
  • Kidney / physiology
  • Male
  • Renal Artery

Substances

  • Angiotensin II
  • Creatinine