AIDS: decline and fall of immune surveillance?

Curr Biol. 1997 Mar 1;7(3):R136-40. doi: 10.1016/s0960-9822(97)70072-1.

Abstract

Recent observations cast doubt on the view that cytotoxic T cells play a key role in keeping HIV-1 infection in check, and that it is the decline in this mechanism of immune surveillance that permits progression to AIDS.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Acquired Immunodeficiency Syndrome / virology
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Disease Progression
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV Infections / pathology
  • HIV Infections / virology
  • HIV-1 / drug effects
  • HIV-1 / immunology
  • HIV-1 / physiology
  • Humans
  • Immunologic Surveillance*
  • Models, Immunological
  • RNA, Viral / blood
  • T-Lymphocytes, Cytotoxic / immunology*
  • Viremia / drug therapy
  • Viremia / virology
  • Virus Replication

Substances

  • Anti-HIV Agents
  • RNA, Viral