Today, prescribers need to distinguish between the clinical practices based on randomized clinical trialing information and those based on animal physiological data or theory. Now the information on therapeutics is becoming more dense, more complex and less available to the clinicians. Information sources are numerous and varied, including data whose quality differs. These data are unhierarchised in terms of methodological quality and clinical relevance. It will be optimal if each prescriber could himself collect and analyse scientific information. In fact this situation cannot be effective in private physician's practices. An international collaboration, the Cochrane Collaboration, including volunteers, university researchers, and clinical investigators has the following objective: to prepare, maintain and disseminate systematic reviews of the effects of health care. The Cochrane Collaboration is thus the most adapted intermediairy between scientifically actualized data and clinical practitioners.