Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene

Clin Genet. 1996 Dec;50(6):555-7. doi: 10.1111/j.1399-0004.1996.tb02738.x.

Abstract

We examined 63 unrelated individuals from the United States for the Apa-LI polymorphism in intron 5 of the WT1 gene. Allele frequencies of 0.13 and 0.87 for the A and B alleles, respectively, and a heterozygosity index of 24% contrast sharply with previous data obtained in the Japanese population where allele frequencies of 0.55 and 0.45 for the A and B alleles and a heterozygosity index of 59% were reported. These data suggest genetic heterogeneity at the WT1 locus, which may contribute to the differences in the incidence of Wilms tumor between the two population groups.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • DNA-Binding Proteins / genetics
  • Epistasis, Genetic
  • Gene Frequency
  • Genes, Wilms Tumor*
  • Genetic Variation*
  • Heterozygote
  • Humans
  • Incidence
  • Introns / genetics*
  • Japan / epidemiology
  • Kidney Neoplasms / epidemiology
  • Kidney Neoplasms / genetics
  • Polymorphism, Restriction Fragment Length*
  • Sequence Deletion
  • Transcription Factors / genetics
  • United States / epidemiology
  • WT1 Proteins
  • Wilms Tumor / epidemiology
  • Wilms Tumor / genetics

Substances

  • DNA-Binding Proteins
  • Transcription Factors
  • WT1 Proteins