Enantiomeric resolution by HPLC of axial chiral amides using amylose tris[(S)-1-phenylethylcarbamate]

Chirality. 1997;9(2):109-12. doi: 10.1002/(SICI)1520-636X(1997)9:2<109::AID-CHIR6>3.0.CO;2-C.

Abstract

The enantiomeric resolution of a series of N-arylamides was examined on amylose tris[(S)-1-phenylethylcarbamate] coated onto aminopropylated 7 microns silica with 500 A diameter pores and on naked silica 5 microns particle size with 500 A diameter pores. The enantiomeric resolution obtained for this series was excellent on both columns. The enantioselectivity of cellulose and amylose tris(3,5-dimethylphenylcarbamate) coated onto APS-Hypersil (120 A pore size, 5 microns particle size) was also investigated for this series of compounds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemistry
  • Amides / isolation & purification*
  • Amylose / analogs & derivatives*
  • Amylose / chemistry
  • Cellulose
  • Chromatography, High Pressure Liquid
  • Ion Exchange Resins
  • Particle Size
  • Spectrophotometry, Ultraviolet
  • Stereoisomerism

Substances

  • Amides
  • Ion Exchange Resins
  • amylose tris(1-phenylethylcarbamate)
  • Cellulose
  • Amylose