A 41-kDa antigen of the rodent filaria Acanthocheilonema viteae with homologies to tropomyosin induces host-protective immune responses

Parasitol Res. 1997;83(4):390-3. doi: 10.1007/s004360050269.

Abstract

A purified 41-kDa protein of the rodent filaria Acanthocheilonema viteae was shown to protect jirds against a challenge infection. Subcutaneous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequencing of the purified protein.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Helminth / chemistry
  • Antigens, Helminth / therapeutic use*
  • Dipetalonema / immunology*
  • Dipetalonema Infections / prevention & control*
  • Female
  • Gerbillinae / immunology
  • Gerbillinae / parasitology*
  • Male
  • Molecular Sequence Data
  • Rodent Diseases / prevention & control*
  • Sequence Analysis
  • Sequence Homology, Amino Acid
  • Tropomyosin / chemistry
  • Vaccination*

Substances

  • Antigens, Helminth
  • Tropomyosin