Abstract
A purified 41-kDa protein of the rodent filaria Acanthocheilonema viteae was shown to protect jirds against a challenge infection. Subcutaneous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequencing of the purified protein.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Helminth / chemistry
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Antigens, Helminth / therapeutic use*
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Dipetalonema / immunology*
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Dipetalonema Infections / prevention & control*
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Female
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Gerbillinae / immunology
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Gerbillinae / parasitology*
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Male
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Molecular Sequence Data
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Rodent Diseases / prevention & control*
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Sequence Analysis
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Sequence Homology, Amino Acid
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Tropomyosin / chemistry
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Vaccination*
Substances
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Antigens, Helminth
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Tropomyosin