To adequately assess isokinetic human muscle performance, it is important for clinicians to understand how the muscle functions across a range of velocities. Thus, the purpose of this study was to re-examine the in vivo quadriceps torque-velocity relationship using trend analysis. Twelve uninjured university-age females performed three concentric and eccentric contractions at velocities of 0, 25, 50, 75, 100, 125, 150, 175, and 200 degrees/sec on the Kin-Com isokinetic dynamometer. A trend analysis was performed on the angle-specific torques at 30, 60, and 75 degrees of knee flexion. The results indicated that the concentric and eccentric relationships at 30 degrees and the concentric relationship at 60 degrees were represented by a third-order polynomial, and a linear relationship was found for concentric contractions at 75 degrees. There were no significant trends for the eccentric relationship at 60 and 75 degrees, suggesting that they were best described by the grand mean. These results suggest that muscular torque production varies across velocities and contraction modes and that this relationship varies depending on the joint angle of torque measurement.