BCG specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent PPD reactive cells

Immunol Invest. 1997 Apr;26(3):323-31. doi: 10.3109/08820139709022689.

Abstract

The effect of tuberculosis anergic immune sera adsorbed with BCG was studied on cocultures of adherent and non-adherent cells from PPD+ tuberculosis patient (TBP PPD+). This effect on the cocultures was quantified by lymphocyte transformation (LT) test using PPD as antigen. Only those cocultures with non-adherent cells from TBP PPD+ patients treated with anergic sera, inhibited the LT response induced by PPD, whereas sera adsorption with BCG eliminated the inhibitory effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Antibodies, Bacterial / immunology
  • BCG Vaccine / immunology*
  • BCG Vaccine / pharmacology*
  • Cell Adhesion / physiology
  • Cells, Cultured
  • Humans
  • Lymphocyte Activation
  • Mycobacterium tuberculosis / immunology
  • Sensitivity and Specificity
  • Tuberculin Test
  • Tuberculosis, Pulmonary / blood*
  • Tuberculosis, Pulmonary / immunology*

Substances

  • Antibodies, Bacterial
  • BCG Vaccine